Open Enrollment for Non- Small-Cell Lung Cancer

Cancer cells can use a variety of strategies to evade the body’s natural immune defenses. PD-L1 is a protein found on normal human cells that helps prevent the immune system from attacking healthy tissue. Some cancer cells exploit this protective mechanism by expressing PD-L1, allowing them to hide from immune system cells and avoid destruction.

The PADLINK-005 clinical trial is studying an investigational treatment designed to target PD-L1 on tumor cells and deliver an anti-cancer drug directly to them. This study medicine is an Antibody-Drug Conjugate (ADC)—a type of therapy engineered to carry cancer-fighting medication straight to tumor cells.

Unlike traditional “systemic” cancer treatments that affect both healthy and cancerous cells throughout the body, ADCs are designed to work more precisely. By targeting PD-L1–expressing cancer cells, this approach aims to deliver treatment directly to the tumor while limiting impact on healthy cells.

About Clinical Trials

Clinical trials are essential for advancing modern medicine. They help researchers understand how safe and effective potential treatments are before they become available to the public. Every medicine, vaccine, and health device approved today was first tested in clinical trials involving volunteers.

Why Participate in a Clinical Trial?

• Contribute to Science: Your participation helps researchers learn more about health conditions and treatments.
• Close Monitoring: While direct benefits are not guaranteed, your health will be closely monitored by the study team.
• Personal Choice: Joining a clinical trial is voluntary. You can leave at any time, for any reason.

Your Safety Comes First

Safety is always the top priority. Before you decide to participate, you’ll receive detailed information about the trial, including potential benefits and risks. Your health will be monitored throughout the study.

What to Expect

Before the Trial

• Pre-Screening: Answer questions about your health and medical history.
• Informed Consent: Review trial details and sign a consent form (not a contract).
• Screening: Additional questions and tests to confirm eligibility.

During the Trial

• Treatment: Receive the study medicine or vaccine and complete trial activities at the clinic or at home.
• Follow-Up: Short-term or long-term visits to monitor your health after treatment.

After the Trial:

Participants can view a summary of trial results about 12 months after completion by registering at pfizerclinicaltrialalumni.com.

Questions to Ask Before Joining

• What is the purpose of this trial?
• What chance do I have of receiving the study medicine?
• Has this treatment been researched before?
• What are the possible side effects?
• Can I take other medications during the trial?
• What costs will be covered?
• Can I still see my regular doctor?
• Will joining affect future treatment options?